The Revolver magazine ceremony took place at the Club Nokia venue in Los Angeles and featured a closing set by Manson, who performed with Pretty Reckless singer Taylor Momsen before introducing Depp to the stage.
The actor, who began his career in music before turning to Hollywood, thrilled the crowd by playing guitar with Manson on his cover of the Eurythmics' 'Sweet Dreams' and hit track 'The Beautiful People.'
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During the show, Motley Crue star Nikki Sixx was presented with the Paul Gray Best Bassist prize, named in honor of the late Slipknot musician who died in 2010, and former Guns N' Roses star Slash was named Riff Lord.
Slash also put in one of the night's most memorable performances by taking to the stage with rock legend Alice Cooper for a rendition of 'School's Out.'
The guitarist subsequently wrote in a post on his Twitter.com page, "Now, that was a kick a** event! Fn' (f**king) great people/artists representing everywhere u (sic) turned. Good fn' (f**king) times! & thanks for the honor!"
The ceremony's special Golden God prize went to Kiss rocker Gene Simmons, who called the trophy "an honor and privilege", while Jack Black's band Tenacious D presented the Ronnie James Dio Lifetime Achievement Award to Canadian stars Rush.
Black told the crowd, "Can anyone imagine a world without 'Tom Sawyer'? These songs and many others have become part of our collective DNA. They either inspired you enough to pick up an instrument and practice like hell...", before his bandmate Kyle Gass added: "Or, let's be honest, discouraged you from even trying to approach their technical prowess."
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